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SEARCHING FOR A THERAPY QUESTION
For a quick answer to any evidence-based question, the format for a PubMed search is the same:
1) Search for the disease/condition
2) Search for the intervention (drug, surgery, diagnostic test, screening test, prognostic indicator)
3) Add the appropriate "filter" for that particular type of question.
The proper filter for a therapy question is to search for the desired level of evidence. For a therapy question, the highest level of evidence would be a meta-analysis, followed by a systematic review, and then a single prospective randomized blinded placebo-controlled clinical trial.
For example, if you wanted to search for information on whether it would be appropriate to use the antibiotic amoxicillin for a six-month old with otitis media, you would take the following steps.
1) Click on the link at the bottom of the screen to enter the MeSH database.